Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 743)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2122084	0.1062925	0.0590116
Weighted median	23	0.0717284	0.0592463	0.2260171
Inverse variance weighted	23	0.0857372	0.0421749	0.0420630
Simple mode	23	-0.0424450	0.1138349	0.7128176
Weighted mode	23	-0.0270368	0.1046523	0.7985394

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.81387	21	0.3021641
Inverse variance weighted	25.70879	22	0.2643948

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0077668	0.0060083	0.2101652

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009253	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8