Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 742)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0533188	0.0998188	0.5988436
Weighted median	23	-0.0417720	0.0581383	0.4724531
Inverse variance weighted	23	-0.0211565	0.0390153	0.5876378
Simple mode	23	-0.0950119	0.1126343	0.4080036
Weighted mode	23	-0.1244498	0.0943748	0.2008410

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.63767	21	0.8846542
Inverse variance weighted	13.76020	22	0.9097710

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019751	0.0056423	0.7297851

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004259	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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