Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 741)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0020614	0.0998197	0.9837186
Weighted median	23	0.0526401	0.0592300	0.3741428
Inverse variance weighted	23	0.0595970	0.0390153	0.1266296
Simple mode	23	0.0680470	0.1013122	0.5087943
Weighted mode	23	0.0595906	0.0741747	0.4303491

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.42641	21	0.4944144
Inverse variance weighted	20.87676	22	0.5283655

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0037865	0.0056423	0.5094831

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007033	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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