Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 740)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0213857	0.0998200	0.8324243
Weighted median	23	-0.0187167	0.0529910	0.7239349
Inverse variance weighted	23	-0.0448402	0.0390158	0.2504384
Simple mode	23	0.0002732	0.0870983	0.9975257
Weighted mode	23	-0.0490715	0.0632304	0.4459688

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.44893	21	0.7439212
Inverse variance weighted	16.51409	22	0.7895787

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0014403	0.0056423	0.8009941

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005405	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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