Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 74)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1797103	0.0998209	0.0861917
Weighted median	23	-0.0450985	0.0557878	0.4188645
Inverse variance weighted	23	0.0052316	0.0390158	0.8933323
Simple mode	23	-0.0352477	0.0889894	0.6958553
Weighted mode	23	-0.0383380	0.0654176	0.5638072

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.75152	21	0.6646701
Inverse variance weighted	21.80311	22	0.4716921

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0113572	0.0056423	0.0571275

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006612	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8