Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 739)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0742436	0.1108892	0.5104531
Weighted median	23	-0.1048715	0.0578113	0.0696732
Inverse variance weighted	23	-0.0860189	0.0423593	0.0422861
Simple mode	23	-0.1720547	0.1074143	0.1234654
Weighted mode	23	-0.1475317	0.0757300	0.0642699

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.91709	21	0.2096280
Inverse variance weighted	25.93352	22	0.2545473

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0007231	0.0062681	0.9092501

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009331	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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