Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 738)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1813778	0.0998211	0.0835129
Weighted median	23	0.0212145	0.0541351	0.6951461
Inverse variance weighted	23	-0.0037126	0.0390159	0.9241903
Simple mode	23	-0.0107265	0.0851767	0.9009289
Weighted mode	23	0.0139944	0.0590800	0.8149473

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.92189	21	0.9417025
Inverse variance weighted	15.97998	22	0.8168780

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0113663	0.0056423	0.056945

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004845	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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