Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 737)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0390666	0.0998194	0.6994642
Weighted median	23	0.0730754	0.0556952	0.1895000
Inverse variance weighted	23	0.0678041	0.0390153	0.0822315
Simple mode	23	0.1126785	0.0921926	0.2345630
Weighted mode	23	0.0919100	0.0704313	0.2053919

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.70634	21	0.6039717
Inverse variance weighted	18.80417	22	0.6573879

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0017648	0.0056423	0.7575362

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006613	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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