Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 736)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0038874	0.1092946	0.9719628
Weighted median	23	0.0196496	0.0571255	0.7308670
Inverse variance weighted	23	-0.0269557	0.0418298	0.5193067
Simple mode	23	0.0382409	0.1015467	0.7100899
Weighted mode	23	0.0046581	0.0651647	0.9436607

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.17537	21	0.2396487
Inverse variance weighted	25.28805	22	0.2834989

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0018941	0.0061779	0.7621742

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007808	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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