Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 735)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1423132	0.0998207	0.1686545
Weighted median	23	-0.0135069	0.0525165	0.7970296
Inverse variance weighted	23	-0.0018889	0.0390158	0.9613858
Simple mode	23	0.0021571	0.0945724	0.9820086
Weighted mode	23	-0.0433487	0.0617640	0.4901356

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.03748	21	0.6466313
Inverse variance weighted	20.37331	22	0.5597007

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0086234	0.0056423	0.1413508

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006175	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8