Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 734)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0918170	0.1230975	0.4640030
Weighted median	23	0.0104059	0.0609055	0.8643388
Inverse variance weighted	23	0.0111302	0.0479224	0.8163395
Simple mode	23	0.0472503	0.1100162	0.6717470
Weighted mode	23	-0.0055475	0.0744471	0.9412729

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.93608	21	0.0594283
Inverse variance weighted	33.19151	22	0.0592303

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.006322	0.006958	0.37388

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010082	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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