Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 733)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1515163	0.1050163	0.1638311
Weighted median	23	0.0427948	0.0554934	0.4406070
Inverse variance weighted	23	0.0316373	0.0415454	0.4463521
Simple mode	23	0.0283312	0.0853170	0.7429791
Weighted mode	23	0.0283312	0.0573004	0.6259014

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.24319	21	0.3311501
Inverse variance weighted	24.94554	22	0.2996861

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0073617	0.005936	0.2285867

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007758	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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