Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 732)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1044220	0.1216601	0.4004125
Weighted median	23	-0.0438948	0.0568385	0.4399529
Inverse variance weighted	23	0.0272952	0.0479643	0.5693067
Simple mode	23	0.0359944	0.1068769	0.7394716
Weighted mode	23	-0.0309107	0.0661092	0.6446906

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.19471	21	0.0704780
Inverse variance weighted	33.24988	22	0.0584443

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0080887	0.0068768	0.2526642

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010223	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8