Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 731)

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.0146902 0.1203223 0.9039884
Weighted median 23 0.0501003 0.0572170 0.3812368
Inverse variance weighted 23 -0.0368630 0.0459912 0.4228284
Simple mode 23 -0.0021786 0.1025368 0.9832402
Weighted mode 23 0.0576801 0.0597178 0.3446036

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 30.51231 21 0.0821663
Inverse variance weighted 30.57055 22 0.1052436

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0013616 0.0068012 0.8432465

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0009533 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8