Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 730)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0307197	0.1011904	0.7644331
Weighted median	23	-0.0681385	0.0605301	0.2602939
Inverse variance weighted	23	-0.0246932	0.0390154	0.5267925
Simple mode	23	-0.1443026	0.1066955	0.1899636
Weighted mode	23	-0.0901652	0.0704141	0.2137056

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.58045	21	0.4240219
Inverse variance weighted	21.58475	22	0.4848947

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0003701	0.0057198	0.949023

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006662	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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