Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 73)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0150789	0.1153371	0.8972268
Weighted median	23	-0.0117268	0.0567512	0.8362943
Inverse variance weighted	23	-0.0197080	0.0440460	0.6545569
Simple mode	23	0.0090687	0.1070691	0.9332661
Weighted mode	23	0.0172789	0.0897438	0.8490888

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.03653	21	0.1391185
Inverse variance weighted	28.03906	22	0.1743902

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0002843	0.0065194	0.9656327

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008573	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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