Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 729)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0617159	0.1009840	0.5476621
Weighted median	23	0.0873718	0.0566135	0.1227573
Inverse variance weighted	23	0.0446108	0.0397461	0.2616950
Simple mode	23	0.0733514	0.0953019	0.4496795
Weighted mode	23	0.0733514	0.0699291	0.3055935

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.49235	21	0.4292508
Inverse variance weighted	22.83154	22	0.4112936

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0065295	0.0057081	0.2655361

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007315	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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