Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 728)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1778500	0.1108430	0.1235334
Weighted median	23	-0.0062954	0.0601484	0.9166415
Inverse variance weighted	23	0.0004365	0.0453010	0.9923116
Simple mode	23	0.0206621	0.1003833	0.8388147
Weighted mode	23	-0.0083439	0.0748638	0.9122664

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.89441	21	0.2105038
Inverse variance weighted	29.65978	22	0.1269708

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0109486	0.0062654	0.0951644

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008988	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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