Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 727)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0720675	0.1117330	0.5259134
Weighted median	23	0.0363616	0.0542245	0.5024912
Inverse variance weighted	23	0.0355320	0.0427959	0.4063877
Simple mode	23	0.0376777	0.0922576	0.6869301
Weighted mode	23	0.0410017	0.0712190	0.5706517

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.31165	21	0.1948143
Inverse variance weighted	26.46977	22	0.2320597

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0022436	0.0063157	0.7259463

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008272	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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