Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 726)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0478389	0.1255056	0.7069067
Weighted median	23	0.0175212	0.0598009	0.7695283
Inverse variance weighted	23	0.0127028	0.0482394	0.7922975
Simple mode	23	0.1665865	0.1112032	0.1483357
Weighted mode	23	0.0516200	0.0718706	0.4801707

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.19785	21	0.0440688
Inverse variance weighted	33.63203	22	0.0535193

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0037178	0.0070941	0.6057163

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010223	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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