Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 725)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1908602	0.1012497	0.0733379
Weighted median	23	-0.0128839	0.0582053	0.8248185
Inverse variance weighted	23	0.0105053	0.0419705	0.8023528
Simple mode	23	0.1123390	0.1163570	0.3448043
Weighted mode	23	0.0244086	0.0727976	0.7405793

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.60571	21	0.4225277
Inverse variance weighted	25.45886	22	0.2756389

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0110756	0.0057231	0.0665433

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007736	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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