Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 724)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0992616	0.1192787	0.4146699
Weighted median	23	-0.0224454	0.0561507	0.6893519
Inverse variance weighted	23	-0.0603718	0.0477871	0.2064637
Simple mode	23	-0.0563014	0.0900590	0.5382963
Weighted mode	23	-0.0103321	0.0584242	0.8612467

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.98557	21	0.0922784
Inverse variance weighted	33.00423	22	0.0618144

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.009803	0.0067421	0.1607331

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010725	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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