Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 723)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0634767	0.0998206	0.5317064
Weighted median	23	-0.0825497	0.0553713	0.1360040
Inverse variance weighted	23	-0.0629827	0.0390156	0.1064635
Simple mode	23	-0.1216914	0.0888631	0.1846841
Weighted mode	23	-0.0831913	0.0623193	0.1955537

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.19018	21	0.8612924
Inverse variance weighted	14.19021	22	0.8945910

Test for directional horizontal pleiotropy

egger_intercept	se	pval
3.03e-05	0.0056423	0.9957608

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000509	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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