Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 722)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0525811	0.1193679	0.6640788
Weighted median	23	-0.0065173	0.0573845	0.9095764
Inverse variance weighted	23	0.0605189	0.0467190	0.1951889
Simple mode	23	0.0708752	0.1196246	0.5595703
Weighted mode	23	-0.0407959	0.0655791	0.5402793

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.03050	21	0.0913767
Inverse variance weighted	31.54578	22	0.0854765

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0069455	0.0067472	0.3150139

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010288	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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