Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 721)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1637146	0.1111042	0.1554424
Weighted median	23	-0.0893717	0.0598679	0.1354857
Inverse variance weighted	23	-0.0369411	0.0439528	0.4006437
Simple mode	23	-0.1666462	0.1182027	0.1725700
Weighted mode	23	-0.1218193	0.0688047	0.0904997

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.01694	21	0.2058038
Inverse variance weighted	27.92079	22	0.1783211

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0077852	0.0062802	0.2287809

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008732	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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