Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 720)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2033607	0.1008698	0.0567644
Weighted median	23	0.1226612	0.0584896	0.0359806
Inverse variance weighted	23	0.0546939	0.0408033	0.1801064
Simple mode	23	-0.0322602	0.1117738	0.7755739
Weighted mode	23	0.1676246	0.0642762	0.0160626

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.44478	21	0.4320854
Inverse variance weighted	24.06301	22	0.3439354

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0091298	0.0057017	0.1242636

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007887	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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