Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 72)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0573181	0.1041883	0.5880279
Weighted median	23	-0.0102692	0.0569988	0.8570235
Inverse variance weighted	23	0.0224538	0.0399115	0.5737149
Simple mode	23	0.0338308	0.0991072	0.7360749
Weighted mode	23	-0.0113547	0.0749038	0.8808918

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.87818	21	0.3505080
Inverse variance weighted	23.02217	22	0.4004789

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.002141	0.0058892	0.7198296

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007077	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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