Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 719)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0382952	0.1070770	0.7241809
Weighted median	23	0.0586647	0.0580908	0.3125534
Inverse variance weighted	23	0.0244263	0.0409089	0.5504467
Simple mode	23	0.0232418	0.1000964	0.8185333
Weighted mode	23	0.0458774	0.0640652	0.4814594

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.16410	21	0.2851756
Inverse variance weighted	24.18688	22	0.3375102

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0008517	0.0060525	0.8894352

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007448	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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