Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 718)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0551671	0.1145690	0.6351276
Weighted median	23	0.0063331	0.0548900	0.9081459
Inverse variance weighted	23	0.0041998	0.0440793	0.9240946
Simple mode	23	-0.0662353	0.0954826	0.4951362
Weighted mode	23	0.0004038	0.0570478	0.9944167

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.66396	21	0.1499415
Inverse variance weighted	28.08146	22	0.1729974

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0036457	0.006476	0.579425

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008512	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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