Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 717)

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.0726108 0.1032413 0.4895863
Weighted median 23 -0.0457038 0.0589832 0.4384216
Inverse variance weighted 23 -0.0636782 0.0413108 0.1232091
Simple mode 23 -0.0829518 0.1108146 0.4620487
Weighted mode 23 -0.0388821 0.0836204 0.6465128

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 22.46453 21 0.3731785
Inverse variance weighted 24.66488 22 0.3133675

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0083695 0.0058357 0.1662419

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0008281 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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