Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 716)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0194355	0.1171362	0.8698052
Weighted median	23	-0.0562739	0.0585862	0.3367877
Inverse variance weighted	23	-0.0464682	0.0451274	0.3031452
Simple mode	23	-0.0845876	0.1003261	0.4082314
Weighted mode	23	-0.0418657	0.0769261	0.5917548

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.91839	21	0.1159746
Inverse variance weighted	29.43290	22	0.1329115

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0040471	0.0066211	0.5475945

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009349	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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