Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 715)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1030081	0.1471869	0.4917046
Weighted median	23	-0.0383897	0.0554240	0.4885258
Inverse variance weighted	23	-0.0068942	0.0568759	0.9035212
Simple mode	23	-0.0821778	0.0878395	0.3596640
Weighted mode	23	-0.0520161	0.0541735	0.3474015

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	45.65861	21	0.0014182
Inverse variance weighted	46.75291	22	0.0015804

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0059023	0.0083196	0.4858541

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014175	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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