Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 714)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1964848	0.1194623	0.1149102
Weighted median	23	-0.1302278	0.0638518	0.0413967
Inverse variance weighted	23	-0.1270356	0.0460514	0.0058056
Simple mode	23	-0.0497700	0.1141524	0.6670879
Weighted mode	23	-0.1007734	0.0990700	0.3201182

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.08146	21	0.0903633
Inverse variance weighted	30.65288	22	0.1034403

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.004265	0.0067528	0.5344686

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012499	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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