Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 713)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0612638	0.1151885	0.6004073
Weighted median	23	-0.0081619	0.0545280	0.8810143
Inverse variance weighted	23	-0.0179610	0.0441615	0.6842206
Simple mode	23	0.0307083	0.0926106	0.7433407
Weighted mode	23	-0.0040910	0.0625816	0.9484694

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.96398	21	0.1411759
Inverse variance weighted	28.18610	22	0.1695953

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0026592	0.006511	0.6871005

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008605	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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