Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 712)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0420158	0.1012435	0.6823531
Weighted median	23	-0.0333681	0.0562806	0.5532560
Inverse variance weighted	23	-0.0428553	0.0390155	0.2720227
Simple mode	23	-0.0648072	0.0937144	0.4964601
Weighted mode	23	-0.0373701	0.0630385	0.5593512

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.60302	21	0.4226871
Inverse variance weighted	21.60310	22	0.4837812

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-5.16e-05	0.0057227	0.9928975

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006912	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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