Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 711)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0573431	0.1051584	0.5912912
Weighted median	23	0.0106080	0.0574087	0.8534012
Inverse variance weighted	23	0.0746659	0.0418976	0.0747322
Simple mode	23	0.1643730	0.1047532	0.1308863
Weighted mode	23	-0.0058935	0.0640166	0.9274818

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.30595	21	0.3278851
Inverse variance weighted	25.37021	22	0.2797004

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0081066	0.005944	0.187064

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008797	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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