Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 710)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0676501	0.0998206	0.5053503
Weighted median	23	-0.0087226	0.0564724	0.8772485
Inverse variance weighted	23	0.0051442	0.0390156	0.8951040
Simple mode	23	-0.0076373	0.0900747	0.9331964
Weighted mode	23	-0.0152009	0.0702686	0.8307272

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.5382	21	0.8886069
Inverse variance weighted	14.1659	22	0.8954866

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0044703	0.0056424	0.4370593

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004298	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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