Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 71)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0586609	0.1062800	0.5868115
Weighted median	23	0.0942341	0.0603163	0.1182098
Inverse variance weighted	23	0.0527057	0.0405887	0.1941050
Simple mode	23	0.1219551	0.1124416	0.2898381
Weighted mode	23	0.1404868	0.1032227	0.1872909

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.80644	21	0.3025312
Inverse variance weighted	23.81064	22	0.3572329

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0003657	0.0060075	0.9520337

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007768	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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