Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 709)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0415907	0.0998205	0.6811589
Weighted median	23	-0.0228909	0.0555391	0.6802228
Inverse variance weighted	23	-0.0216074	0.0390156	0.5797071
Simple mode	23	-0.0657126	0.0896366	0.4712371
Weighted mode	23	-0.0364665	0.0667255	0.5902124

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.50968	21	0.6797859
Inverse variance weighted	17.55699	22	0.7319076

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0012272	0.0056423	0.8299226

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005413	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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