Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 708)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1396527	0.0998198	0.1763958
Weighted median	23	-0.0949119	0.0539894	0.0787524
Inverse variance weighted	23	-0.0709917	0.0390154	0.0688226
Simple mode	23	-0.1142385	0.0863005	0.1991844
Weighted mode	23	-0.1058012	0.0620924	0.1024794

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.36063	21	0.5620182
Inverse variance weighted	19.91908	22	0.5881017

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0042165	0.0056423	0.4631713

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007039	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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