Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 707)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0843478	0.1159020	0.4748025
Weighted median	23	-0.0056785	0.0605422	0.9252727
Inverse variance weighted	23	0.0290088	0.0445427	0.5148789
Simple mode	23	0.0049612	0.1130845	0.9654027
Weighted mode	23	0.0213810	0.0740144	0.7753807

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.31237	21	0.1315124
Inverse variance weighted	28.67515	22	0.1543712

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0033984	0.0065514	0.6093734

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008857	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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