Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 706)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0160279	0.0998208	0.8739689
Weighted median	23	0.0113445	0.0529601	0.8303847
Inverse variance weighted	23	0.0006628	0.0390159	0.9864453
Simple mode	23	-0.0044419	0.0804129	0.9564474
Weighted mode	23	0.0104737	0.0608945	0.8650125

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.53387	21	0.7389456
Inverse variance weighted	16.56687	22	0.7867920

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.001025	0.0056423	0.8575928

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000502	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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