Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 705)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0908536	0.0998207	0.3730632
Weighted median	23	0.0819112	0.0546769	0.1341087
Inverse variance weighted	23	0.0630078	0.0390156	0.1063239
Simple mode	23	0.0829494	0.0952523	0.3932458
Weighted mode	23	0.0939103	0.0617880	0.1427836

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.90952	21	0.6547223
Inverse variance weighted	18.00137	22	0.7059068

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.00171	0.0056424	0.7648213

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006245	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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