Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 704)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0069049	0.0998209	0.9455064
Weighted median	23	-0.0416709	0.0539549	0.4399202
Inverse variance weighted	23	-0.0245594	0.0390158	0.5290398
Simple mode	23	-0.0508456	0.0904820	0.5798367
Weighted mode	23	-0.0385888	0.0616072	0.5375194

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	9.435118	21	0.9853564
Inverse variance weighted	9.552389	22	0.9899292

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019322	0.0056424	0.7354167

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003015	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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