Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 703)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0718791	0.0998207	0.4794136
Weighted median	23	-0.0243796	0.0561312	0.6640475
Inverse variance weighted	23	0.0076229	0.0390157	0.8450944
Simple mode	23	-0.0324957	0.0847943	0.7052277
Weighted mode	23	-0.0302456	0.0665685	0.6540253

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.65325	21	0.8399402
Inverse variance weighted	15.40196	22	0.8444182

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0048822	0.0056423	0.3966626

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004679	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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