Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 702)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0896899	0.1020691	0.3894987
Weighted median	23	0.0248064	0.0559382	0.6574323
Inverse variance weighted	23	0.0114056	0.0400377	0.7757418
Simple mode	23	0.0792805	0.0869412	0.3717132
Weighted mode	23	0.0294844	0.0645594	0.6523625

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.95703	21	0.4019898
Inverse variance weighted	23.16771	22	0.3923120

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0062083	0.0057694	0.2941072

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007046	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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