Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 701)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0711205	0.0998208	0.4840083
Weighted median	23	0.0337570	0.0543136	0.5342569
Inverse variance weighted	23	0.0479298	0.0390157	0.2192694
Simple mode	23	0.0193749	0.0806154	0.8122941
Weighted mode	23	0.0285965	0.0636476	0.6576146

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.47129	21	0.7985832
Inverse variance weighted	15.53499	22	0.8382750

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0014241	0.0056423	0.8031843

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005165	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8