Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 700)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0206512	0.1057330	0.8470237
Weighted median	23	0.0167849	0.0586248	0.7746398
Inverse variance weighted	23	-0.0059782	0.0404484	0.8825026
Simple mode	23	-0.0855814	0.0989995	0.3966619
Weighted mode	23	0.0081293	0.0665205	0.9038438

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.56131	21	0.3147960
Inverse variance weighted	23.64531	22	0.3660925

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0016353	0.0059765	0.7870484

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007172	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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