Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 70)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0216341	0.1314733	0.8708710
Weighted median	23	0.0758066	0.0577422	0.1892348
Inverse variance weighted	23	-0.0101003	0.0502880	0.8408161
Simple mode	23	0.0964069	0.0951031	0.3217414
Weighted mode	23	0.0995766	0.0794984	0.2235169

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.43054	21	0.0195508
Inverse variance weighted	36.54984	22	0.0264897

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019488	0.0074315	0.7956951

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011095	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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