Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 7)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0525204	0.0998205	0.6042984
Weighted median	23	0.0140687	0.0542823	0.7954987
Inverse variance weighted	23	-0.0026990	0.0390155	0.9448480
Simple mode	23	-0.0278452	0.0906876	0.7616968
Weighted mode	23	0.0038590	0.0740537	0.9589105

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.58973	21	0.6114402
Inverse variance weighted	18.88376	22	0.6524952

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0030595	0.0056423	0.5933588

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005724	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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